System and method for changing transmission from an in vivo sensing device

ABSTRACT

A device, system and method enables obtaining data such as in vivo images from within body lumens or cavities, such as images of the gastrointestinal (GI) tract. A device may include an imaging system and a radio frequency (RF) transmitter for transmitting signals from an imaging device to a receiving system. The signal strength of the transmitter may be varied or changed to account for, for example, the amount of signal attenuation resulting from body tissues.

PRIOR PROVISIONAL APPLICATION

The present application claims benefit from prior U.S. provisionalapplication No. 60/306,872 entitled “VARIABLE SIGNAL STRENGTH IMAGINGDEVICE” and filed on Jul. 23, 2001.

FIELD OF THE INVENTION

The present invention relates to an in vivo sensing device, system andmethod such as for imaging the digestive tract; more specifically, to anin vivo sensing device utilizing a device, system and method whereby thetransmission signal strength may be varied.

BACKGROUND OF THE INVENTION

Devices and methods for sensing of passages or cavities within a body,and for gathering information (e.g., image data, pH data, temperatureinformation, pressure information), are known in the art. Such devicesmay include, inter alia, various endoscopic imaging systems and devicesfor performing imaging in various internal body cavities. Some devicestransmit the collected data to an external receiving unit.

An in-vivo imaging device may include, for example, an imaging systemfor obtaining images from inside a body cavity or lumen, such as thegastrointestinal (GI) tract. The imaging system may include, forexample, an illumination unit, such as a set of light emitting diodes(LEDs), or other suitable light sources. The device may include animaging sensor and an optical system, which focuses the images onto theimaging sensor. A transmitter and antenna may be included fortransmitting the images signals. A receiver/recorder, for example wornby the patient, may record transmitted image data and store image andother data. The recorded data may then be downloaded from thereceiver/recorder to a computer or workstation for display and analysis.

A signal transmitted from an in vivo sensor may be attenuated whilepassing through the body tissues, due to the fact that tissues haveelectrical conductance. Continuous high-level transmission, which mightovercome the attenuation, may require a continuous supply of highenergy, may be inefficient and may be in conflict with regulatoryconsiderations.

Therefore, there is a need for an in-vivo sensing device, such as animaging device, which may transmit data at efficient power levels.

SUMMARY OF TE INVENTION

An embodiment of the device, system and method of the present inventionenables obtaining in vivo images from within body lumens or cavities,such as images of the gastrointestinal (GI) tract. One embodiment of theinvention provides a device including an imaging system and a radiofrequency (RF) transmitter for transmitting signals from an imagingdevice to a receiving system. In one embodiment of such an imagingsystem, the signal strength of the transmitter may be varied or changedto account for, for example, the amount of signal attenuation resultingfrom body tissues.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows a schematic diagram of an in vivo imaging system accordingto one embodiment of the present invention; and

FIG. 2 shows a block diagram of a method for changing data transmittedfrom an in vivo sensing device, according to an embodiment of theinvention.

DETAILED DESCRIPTION OF TE INVENTION

In the following description, various aspects of the present inventionwill be described. For purposes of explanation, specific configurationsand details are set forth in order to provide a thorough understandingof the present invention. However, it will also be apparent to oneskilled in the art that the present invention may be practiced withoutthe specific details presented herein. Furthermore, well known featuresmay be omitted or simplified in order not to obscure the presentinvention.

The device, system and method of the present invention may be used withan imaging system or device such as that described in WO 01/65995entitled “A Device And System For In Vivo Imaging”, published on 13 Sep.2001, which is hereby incorporated by reference. However, the device,system and method according to the present invention may be used withany device providing data from a body lumen or cavity. For example, thedevice, system and method of the present invention may be used withimaging devices using cameras other than CMOS imaging cameras. Inalternate embodiments, a known imaging camera of another type such as aCCD may be used. A further example of an imaging system and device withwhich the system and method of the present invention may be used isdescribed in U.S. Pat. No. 5,604,531 entitled “In Vivo Video CameraSystem,” which is incorporated herein by reference. In furtherembodiments, the system and method of the present invention may be usedwith devices and systems capturing information other than imageinformation within the human body; for example, pressure or pHinformation, information on the location of a transmitting device, orother information.

Reference is made to FIG. 1, which shows a schematic diagram of an invivo sensor according to one embodiment of the present invention. In anexemplary embodiment, the system includes a device 40 having an imagesensor 46, for capturing images, an optical system (not shown), anillumination source 42 (which may be, for example, one or more LEDs,although any suitable illumination source), for illuminating the bodylumen, and a transmitter 41 and antenna 44, for transmitting image andpossibly other information to a receiving device. Typically, the device40 is an ingestible capsule capturing images, but may be another sort ofdevice and may collect information other than image information. Anoptical system (not shown), including, for example, lenses or mirrors,may aid in focusing reflected light onto the imager 46. The device 40typically includes a power source 47 which may be, for example, one ormore a batteries or other power sources.

The device 40 may be swallowed or otherwise ingested by a patient andtypically traverses the patient's GI tract. In one embodiment,transmitter 41 provides control and possibly other processing capabilityfor the device 40. Thus, transmitter 41 may include or be associatedwith circuitry such as an ASIC, a microcontroller, or a “computer on achip.” In alternate embodiments, a separate control an/or processingunit may be provided.

In one embodiment, the imager 46 is a complementary metal oxidesemiconductor (CMOS) imaging camera. The CMOS imager is typically anultra low power imager, has a low sensitivity to the red spectrum, andis provided in chip scale packaging (CSP). One suitable CMOS camera is,for example, a “camera on a chip” CMOS imager specified by Given ImagingLtd. of Israel and designed by Photobit Corp. of California, USA, withintegrated active pixel and post processing circuitry. Other types ofCMOS imagers may be used. In another embodiment, another imager may beused, such as a CCD imager, or another imager.

In one embodiment, transmitter 41 includes at least a modulator forreceiving an image signal from the imager 46, a radio frequency (RF)amplifier, an impedance matcher and an antenna. The modulator convertsthe input image signal having a cutoff frequency f_(c) of less than 5MHz to an RF signal having a carrier frequency f_(r), typically in therange of 1 GHz. While in one embodiment, the signal is an analog signal,the modulating signal may be digital rather than analog. The carrierfrequency may be in other bands, e.g. a 400 MHz band. The modulated RFsignal has a bandwidth of ft. The impedance matcher matches theimpedance of the circuit to that of the antenna. Other transmitters orarrangements of transmitter components may be used. For example,alternate embodiments may not include a matched antenna or may include atransmitter without a matching circuit. In alternate embodiments, thedevice 40 may have different configurations and include other sets ofcomponents. Other frequencies may be used. In yet further embodimentssensors other than image sensors may be used, such as pH meters,temperature sensors, pressure sensors, etc. and input RF signals otherthan image signals may be used.

According to one embodiment, while the device 40 traverses a patient'sGI tract, the device 40 transmits image and possibly other data tocomponents located outside the patient's body, which receive and processthe data. Typically, located outside the patient's body in one or morelocations, are an image receiver 12, typically including an antenna 15or antenna array, an image receiver storage unit 16, a data processor14, a data processor storage unit 19, and an image monitor 18, fordisplaying, inter alia, the images transmitted by the device 40 andrecorded by the image receiver 12. According to one embodiment, theimage receiver 12 and image receiver storage unit 16 are small andportable, and are worn on the patient's body during recording of theimages. Typically, data processor 14, data processor storage unit 19 andmonitor 18 are part of a personal computer or workstation, whichincludes standard components such as processor 14, a memory, a diskdrive, and input-output devices, although alternate configurations arepossible.

In alternate embodiments, the data reception and storage components maybe of another configuration. Further, image and other data may bereceived in other manners, by other sets of components. Typically, inoperation, image data is transferred to the data processor 14, which, inconjunction with, for example, a central processing unit and software,stores, possibly processes, and displays the image data on monitor 18.Other systems and methods of storing and/or displaying collected imagedata may be used.

Typically, the device 40 transmits image information in discreteportions. Each portion typically corresponds to an image or frame. Othertransmission methods are possible. For example, the device 40 maycapture an image once every half second, and, after capturing such animage, transmit the image. Other capture rates are possible. Typically,the image data recorded and transmitted is digital color image data,although in alternate embodiments other image formats (e.g., black andwhite image data) may be used. In one embodiment, each frame of imagedata includes 256 rows of 256 pixels each, each pixel including data forcolor and brightness, according to known methods. For example, in eachpixel, color may be represented by a mosaic of four sub-pixels, eachsub-pixel corresponding to primaries such as red, green, or blue (whereone primary is represented twice). The brightness of the overall pixelmay be recorded by, for example, a one byte (i.e., 0–255) brightnessvalue. Other data formats may be used.

The receiver 12 typically detects a signal having the carrier frequencyf_(r) and the bandwidth f_(c) described hereinabove. The receiver 12 maybe similar to those found in televisions or it may be one similar tothose described on pages 244–245 of the book Biomedical Telemetry by R.Stewart McKay and published by John Wiley and Sons, 1970. The receivermay be digital or analog. In alternate embodiments, other receivers maybe used.

The location of the imaging device 40 inside the body and itsorientation relative to the antenna(s) 15 change as the device 40traverses the GI tract. At times the device 40 may be located close tothe body surface, and at other times it may be located deeper inside thebody. The signal transmitted from the device 40 may be attenuated whilepassing through the body tissues, due to the fact that tissues haveelectrical conductance. The level of attenuation may be affected by,inter alia, the amount and types of body tissue that the signal passesthrough, and on the transmission frequency. Attenuation typicallyincreases logarithmically with the frequency. In one embodiment of suchan imaging device 40, transmission occurs at a frequency of 434 MHz,using Phase Shift Keying (PSK); the body tissue attenuation at thisfrequency is approximately 2.5–3 dB/cm. In alternate embodiments, othertransmission frequencies and other methods (such as AM or FM) may beused.

One method for maintaining a reliable communication channel forpractically all possible (or likely) locations of the device 40 insidethe body is to set the transmission power of the transmitter 41 in thedevice 40 to some maximum amount such that proper transmission betweenthe device 40 and the antenna 15 or antenna array is achieved for alllocations. For example, assuming that the maximal depth in the body, ofwhich the device 40 is to traverse (e.g., the GI tract) is 25 cm, thetransmitter 41 transmission output should be higher than the minimumpower level required by the receiver 12 by, for example, 3 dB/cm* 25cm=75 dB; the total power level required is the minimum required levelof the receiver 12 plus 75 dB. The minimum required level is a typicallyempirical value which depends, inter alia, on the sensitivity of thereceiver 12, on the modulation technique being used as well as on thespecific design of the receiver 12. In such an “open loop” embodiment,high-level transmission levels occur continually, even when lower powertransmission may be satisfactory. High power transmission requires thetransmitter 41 to consume high levels of power; if the system operateson batteries, the batteries are emptied faster. Further, governmentregulatory considerations may limit transmission levels.

In one embodiment of the device, system and method of the presentinvention, a “closed loop” is used, with feedback from the receiver 12or another module altering the power transmission level of thetransmitter 41 in the device 40 in order to ensure that the power levelis high enough, but not higher than necessary, or not significantlyhigher than necessary, to allow for acceptable transmission quality.Typically, the receiver 12 measures the power level of the receivedsignal from the imaging or other device 40. Various known methods ofmeasuring the strength of the received signal may be used. In oneembodiment, at the start of the transmission of an image frame or otherunit of transmission, a blank or dummy section is sent. During thetransmission of this section, the receiver 12 samples signals from eachof typically multiple antennas in the antenna array 15, and determineswhich antenna is receiving and is the source of the strongest signal.This antenna is used to receive the image frame, and the strength ofthis signal determines the signal strength. In alternate embodiments,only one antenna may be used, and this antenna is then used to determinesignal strength. Embodiments of the present invention may be used withdevices or systems not transmitting “frames” of data, and may be usedwith systems transmitting data continuously.

In one embodiment, to regulate the signal strength of the transmitter41, if the receiver 12 determines that the signal strength is below alower threshold which will result in clear transmission, it determinesthat the signal strength of the transmitter 41 should be increased, andif the image receiver 12 determines that the signal strength is above anupper threshold, it determines that the signal strength of thetransmitter 41 should be decreased. In alternate embodiments, othermethods of controlling the signal strength may be used. For example,after each frame is received, the received signal strength may beevaluated and the signal strength of the transmitter 41 may be adjusted.A blank frame need not be used.

A power level transmitter 13 within the receiver 12, typically a simpletransmitter (e.g., a transmitter transmitting a relatively small amountof information using simple modulation or Frequency Shift Keying (FSK),using a relatively low frequency signal), transmits a signal to thedevice 40 regarding the power level of the received signal. In theimaging or other device 40 a typically simple power level receiver 43(e.g., a simple RF receiver, such as a receiver in the alarm of a car)may be used to receive and decode power level information, and theoutput power of the transmitter within the device 40 is changedaccordingly.

Typically, the power level transmitter 13 may transmit a command from apre-determined set of commands. The receiver 43 may receive and decodethe command, and transfer it to the transmitter 41, in order to set theoutput power level. In alternate embodiments, other power levelinformation may be used; for example, a signal to raise or lower thepower level by a certain amount, or a signal indicating the power levelor signal quality. In further embodiments, processing capability may beincluded in the device 40 for adjusting the power level based on suchsignals. According to one embodiment a processing unit may be includedin the device 40 for processing the power level data received from thepower level transmitter 13 and for commanding the transmitter 41 toadjust the transmission level. In one embodiment, transmitter 41 mayprovide processing unit capabilities, thus transmitter 41 may adjust itsown power levels. According to alternate embodiments a processing unitmay be included in the receiver 12 for processing the signal receivedfrom transmitter 41 and for regulating the signal transmitted from powerlevel transmitter 13. The transmitter 41 may include circuitry, whichmay enable it to change the level of the output signal, i.e. the levelof the signal that is transmitted through the antenna. The level of thetransmitted signal may be determined by different methods, e.g. it maybe set constant, or may be changed after receiving a command by thepower level receiver 43.

In alternate embodiments, the power level transmitter 13 and power levelreceiver 43 need not be simple devices. In further embodiments, a deviceother than the receiver 12, which may include a power level receiver,may provide feedback to the device 40.

In yet further embodiments the power level transmitter 13 may be used totransmit a constant, typically, periodical and known signal to bereceived by the power level receiver 43. The signal is typicallyattenuated (e.g., by the passage through the body tissues) such that thereceived signal contains information regarding the attenuation. As such,the received signal may provide indication of the transmission strengthrequired from transmitter 41. According to embodiments of the inventionthe device 40 may include a processor, typically, for computing thetransmission strength of a transmitted signal based on a receivedsignal, for example, a signal received from the power level transmitter13.

According to one embodiment two image frames are transmitted from thedevice 40 every second, and with the transmission of each frame, thesignal strength is measured by the receiver 12 and a power levelfeedback signal is provided to the device 40. In alternate embodiments,other rates of imaging and other rates of feedback may be used. Forexample, feedback may be provided once every several frames orperiodically, per a fixed time period.

Reference is now made to FIG. 2, which shows a block diagram of a methodfor changing data transmission from an in vivo sensing device. Accordingto one embodiment the method includes the steps of obtaining atransmission from within a body and in response to the transmission,changing a transmission strength. According to an embodiment of theinvention, the method includes the steps of obtaining a sample of atransmission from within a body (202) to determine the transmissionstrength; comparing the transmission strength to a threshold value(204); and changing (for example, decreasing or increasing) atransmission strength according to the comparison (206). According toone embodiment one transmission event is sampled, for example, bymeasuring the transmission strength of a blank or dummy portion of thetransmission, and the same transmission event is changed. According toanother embodiment one transmission event is sampled and anothertransmission event is changed, for example, transmission n is sampledand the transmission strength of n is determined and compared to athreshold. Transmission n+1 is then changed according to the comparison.Other sampling methods or frequencies may be used.

According to an embodiment of the invention a method for controllingimage data transmission from an in vivo capsule is provided. The methodaccording to an embodiment may include receiving a transmission having asignal strength; evaluating the signal strength; and altering a capsuletransmission power level.

Accordingly, lower average power consumption in the device 40 may beachieved, prolonging battery life (if a battery is used). Furthermore,in situations where the estimated maximum power level is not enough toachieve reliable communication, the power level can be increased by theclosed loop system, allowing for more reliable communication.

It will be appreciated by persons skilled in the art that the presentinvention is not limited to what has been particularly shown anddescribed hereinabove. Alternate embodiments are contemplated which fallwithin the scope of the invention.

1. A system for obtaining in vivo data, the system comprising: aswallowable capsule; and a receiving unit; said swallowable capsulecomprising at least one in vivo sensor, at least one signal transmitterand at least one power level receiver to receive a command to adjust thepower level of said at least one signal transmitter; and said receivingunit comprising at least one receiver and at least one power leveltransmitter.
 2. The system according to claim 1 wherein the power leveltransmitter is configured to transmit data regarding the power level ofa signal transmitted from the signal transmitter and wherein the powerlevel receiver is configured to receive a signal from the power leveltransmitter.
 3. The system according to claim 1 wherein the swallowablecapsule further comprises a processing unit.
 4. The system according toclaim 3 wherein the processing unit is configured to process power leveldata received from the power level transmitter.
 5. The system accordingto claim 3 wherein the processing unit is configured to command thesignal transmitter to change a transmission power level.
 6. The systemaccording to claim 1 wherein the signal transmitter includes an RFtransmitter.
 7. The system according to claim 1 wherein the power leveltransmitter includes an RF transmitter.
 8. The system according to claim1 wherein the receiving unit comprises at least one antenna.
 9. Thesystem according to claim 1 wherein the receiver comprises a pluralityof antennas.
 10. The system according to claim 9 wherein the receivingunit is configured to determine which antenna is receiving the strongestsignal and is configured to sample transmission from the antennareceiving the strongest signal for data regarding power level of asignal transmitted from the signal transmitter.
 11. The system accordingto claim 1 wherein the receiving unit is portable.
 12. The systemaccording to claim 1 wherein at least one in vivo sensor includes animage sensor.
 13. The system according to claim 12 wherein theswallowable capsule further comprises at least one illumination source.14. The system according to claim 1 wherein the at least one in vivosensor is selected from a group consisting of: a temperature sensor, apH meter, and a pressure sensor.
 15. The system according to claim 1wherein the swallowable capsule is an ingestible imaging capsule. 16.The system according to claim 1 wherein the power level receiverincludes an RF receiver.
 17. A method for changing data transmissionfrom a swallowable capsule, the method comprising the steps of:obtaining a data transmission from within a body; in response to thetransmission, transmitting a command to adjust a power level of datatransmission and changing a data transmission strength.
 18. The methodof claim 17 comprising comparing the data transmission strength to athreshold value, wherein the change is according to a comparison. 19.The method according to claim 17 wherein the step of obtaining a datatransmission comprises determining signal strength.
 20. The methodaccording to claim 17 wherein the step of obtaining a data transmissioncomprises measuring the signal strength of a blank portion of thetransmission.
 21. The method according to claim 17 wherein the step ofchanging comprises raising or lowering the transmission strength. 22.The method according to claim 17 wherein the step of changing comprisesraising or lowering the transmission strength by a predetermined value.23. The method according to claim 17 wherein the step of obtaining adata transmission comprises obtaining a sample of a data transmissionand wherein the step of changing a transmission strength compriseschanging the strength of the same transmission.
 24. The method accordingto claim 17 wherein the step of obtaining a data transmission comprisesobtaining a sample of a data transmission and wherein the step ofchanging a transmission strength comprises changing the strength of asubsequent transmission.
 25. The method according to claim 17, whereinthe data transmission includes image data.
 26. The method of claim 17,wherein the swallowable capsule is an imaging capsule.
 27. The methodaccording to claim 17 wherein the step of determining the transmissionstrength comprises the steps of: determining a strongest signal source;and obtaining a data transmission from the strongest signal source. 28.A method for controlling image data transmission from a swallowablecapsule, the method comprising: receiving a data transmission having asignal strength; evaluating the signal strength; transmitting a commandto adjust a power level of data transmission; and altering a capsuledata transmission power level.
 29. A method for changing image datatransmission from a swallowable capsule, the method comprising the stepsof: obtaining a sample of a data transmission of image data from withina body to determine the transmission strength; comparing the datatransmission strength to a threshold value; transmitting a command toadjust a power level of data transmission; and changing a datatransmission strength according to the comparison.
 30. The methodaccording to claim 29 comprising initial steps of: obtaining images froma body lumen; and transmitting image data.
 31. The method according toclaim 29 wherein the step of obtaining images is performed by aningestible imaging capsule.